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KMID : 0861020190340030045
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Korea Journal of Herbology
2019 Volume.34 No. 3 p.45 ~ p.53
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The Effects of Astragali Radix on Hypothyroidism Rat Model Inducedby 6-Propyl-2-thiouracil(PTU)
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Lee Ji-Hye
Koo Jin-Suk
Roh Seong-Soo
Park Ji-Ha
Seo Bu-Il
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Abstract
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Objectives : In present study, we investigated a therapeutic effect of Astragali Radix on hypothyroidism rat model induced by 6-Propyl-2-thiouracil (PTU).
Methods : Six-week-old male Sprague-Dawley rats were divided into five groups : Group one included the normal mice. Group two was administrated PTU. Group three and four were administrated the aqueous extract of Astragali Radix 150 and 300 ㎎/㎏ before start of PTU treatment. Group five (Positive control) was administrated with levothyroxine 0.5 ㎎/㎏. During this moment the body weight, liver H2O2 and catalase (CAT) amount, serum thyroid hormone, serum asparte aminotransferase (AST) and alanine aminotransferase (ALT), gland weights were measured with histopathological changes of thyroid glands. These results were compared with levothyroxine 0.5 ㎎/㎏ treated rats.
Results : The PTU treatment lead to marked decreases of body weight, level of thyroid hormone in serum and liver CAT activation. Also, PTU treatment increased thyroid gland weight, thyroid gland hormone TSH, liver H2O2 amount and level of AST in serum. On the other hands, the administration of Astragali Radix extract increased body weight gains and ameliorated histopathological changes of thyroid such as hyperplasia of follicular cells with of follicular colloid contents and sizes. In addition, the administration of Astragali Radix extract increased level of T4 in serum, CAT activation in liver. Moreover, the administration of Astragali Radix extract decreased levels of TSH and AST in serum and H2O2 amount in liver
Conclusions : This study suggests that Astragali Radix extract has therapeutic effects on hypothyroidism via promoting thyroid hormone production.
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KEYWORD
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Astragali Radix, Hypothyroidism, 6-Propyl-2-thiouracil, PTU
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